Comparison of different cell-cluster models for cell-level dosimetry.
Identifieur interne : 003824 ( Main/Exploration ); précédent : 003823; suivant : 003825Comparison of different cell-cluster models for cell-level dosimetry.
Auteurs : RBID : pubmed:11321669English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Indium Radioisotopes.
- radiotherapy : Neoplasms.
- Cell Aggregation, Humans, Models, Theoretical, Neutron Capture Therapy, Radioimmunotherapy, Radiotherapy Dosage.
Abstract
An important factor in dose calculations for targeted radionuclide therapy is the cell-cluster model used. We developed a cell-cluster model based on optimization through mechanical hard-sphere collisions. The geometrical properties and the dosimetric effects of the new model were compared with those of two previous models, i.e. the traditional lattice model and our CellPacker model in which the cells are individually and systematically piled as a cluster. The choice of the cell-cluster model has an effect on the calculated mean absorbed doses in the cells. While CellPacker produces clusters with distinct tumour-healthy tissue interface, our new model is able to make the interface diffuse. Outside the interface the new model is capable to pack cells tighter than CellPacker enabling the description of tissues of higher cellular density. Our two cluster models make it possible to construct the cluster model according to the tissue in question.
PubMed: 11321669
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of different cell-cluster models for cell-level dosimetry.</title><author><name sortKey="V Lim Ki, J P" uniqKey="V Lim Ki J">J P Välimäki</name><affiliation wicri:level="1"><nlm:affiliation>Medical Engineering Centre, Department of Clinical Neurophysiology, Helsinki University Central Hospital, Finland.</nlm:affiliation><country xml:lang="fr">Finlande</country><wicri:regionArea>Medical Engineering Centre, Department of Clinical Neurophysiology, Helsinki University Central Hospital</wicri:regionArea></affiliation></author><author><name sortKey="Lampinen, J S" uniqKey="Lampinen J">J S Lampinen</name></author><author><name sortKey="Kuronen, A A" uniqKey="Kuronen A">A A Kuronen</name></author><author><name sortKey="Ilvonen, S A" uniqKey="Ilvonen S">S A Ilvonen</name></author><author><name sortKey="Stepanek, J" uniqKey="Stepanek J">J Stepanek</name></author><author><name sortKey="Savolainen, S E" uniqKey="Savolainen S">S E Savolainen</name></author></titleStmt><publicationStmt><date when="2001">2001</date><idno type="RBID">pubmed:11321669</idno><idno type="pmid">11321669</idno><idno type="wicri:Area/Main/Corpus">003A38</idno><idno type="wicri:Area/Main/Curation">003A38</idno><idno type="wicri:Area/Main/Exploration">003824</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Aggregation</term><term>Humans</term><term>Indium Radioisotopes (therapeutic use)</term><term>Models, Theoretical</term><term>Neoplasms (radiotherapy)</term><term>Neutron Capture Therapy</term><term>Radioimmunotherapy</term><term>Radiotherapy Dosage</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Indium Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Aggregation</term><term>Humans</term><term>Models, Theoretical</term><term>Neutron Capture Therapy</term><term>Radioimmunotherapy</term><term>Radiotherapy Dosage</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An important factor in dose calculations for targeted radionuclide therapy is the cell-cluster model used. We developed a cell-cluster model based on optimization through mechanical hard-sphere collisions. The geometrical properties and the dosimetric effects of the new model were compared with those of two previous models, i.e. the traditional lattice model and our CellPacker model in which the cells are individually and systematically piled as a cluster. The choice of the cell-cluster model has an effect on the calculated mean absorbed doses in the cells. While CellPacker produces clusters with distinct tumour-healthy tissue interface, our new model is able to make the interface diffuse. Outside the interface the new model is capable to pack cells tighter than CellPacker enabling the description of tissues of higher cellular density. Our two cluster models make it possible to construct the cluster model according to the tissue in question.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">11321669</PMID><DateCreated><Year>2001</Year><Month>04</Month><Day>25</Day></DateCreated><DateCompleted><Year>2001</Year><Month>05</Month><Day>03</Day></DateCompleted><DateRevised><Year>2009</Year><Month>05</Month><Day>12</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0284-186X</ISSN><JournalIssue CitedMedium="Print"><Volume>40</Volume><Issue>1</Issue><PubDate><Year>2001</Year></PubDate></JournalIssue><Title>Acta oncologica (Stockholm, Sweden)</Title><ISOAbbreviation>Acta Oncol</ISOAbbreviation></Journal><ArticleTitle>Comparison of different cell-cluster models for cell-level dosimetry.</ArticleTitle><Pagination><MedlinePgn>92-7</MedlinePgn></Pagination><Abstract><AbstractText>An important factor in dose calculations for targeted radionuclide therapy is the cell-cluster model used. We developed a cell-cluster model based on optimization through mechanical hard-sphere collisions. The geometrical properties and the dosimetric effects of the new model were compared with those of two previous models, i.e. the traditional lattice model and our CellPacker model in which the cells are individually and systematically piled as a cluster. The choice of the cell-cluster model has an effect on the calculated mean absorbed doses in the cells. While CellPacker produces clusters with distinct tumour-healthy tissue interface, our new model is able to make the interface diffuse. Outside the interface the new model is capable to pack cells tighter than CellPacker enabling the description of tissues of higher cellular density. Our two cluster models make it possible to construct the cluster model according to the tissue in question.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Välimäki</LastName><ForeName>J P</ForeName><Initials>JP</Initials><Affiliation>Medical Engineering Centre, Department of Clinical Neurophysiology, Helsinki University Central Hospital, Finland.</Affiliation></Author><Author ValidYN="Y"><LastName>Lampinen</LastName><ForeName>J S</ForeName><Initials>JS</Initials></Author><Author ValidYN="Y"><LastName>Kuronen</LastName><ForeName>A A</ForeName><Initials>AA</Initials></Author><Author ValidYN="Y"><LastName>Ilvonen</LastName><ForeName>S A</ForeName><Initials>SA</Initials></Author><Author ValidYN="Y"><LastName>Stepanek</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Savolainen</LastName><ForeName>S E</ForeName><Initials>SE</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Comparative Study</PublicationType><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Norway</Country><MedlineTA>Acta Oncol</MedlineTA><NlmUniqueID>8709065</NlmUniqueID><ISSNLinking>0284-186X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Cell Aggregation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Models, Theoretical</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Neoplasms</DescriptorName><QualifierName MajorTopicYN="Y">radiotherapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Neutron Capture Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radioimmunotherapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Radiotherapy Dosage</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>4</Month><Day>26</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>5</Month><Day>5</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>4</Month><Day>26</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11321669</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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